Sedation Medication Dosages


Procedure Dosage Unit Lower Upper Units Sig Max Dose
Etomidate
General Anesthesia (IV – Induction) mg 0.2 0.6 mg/kg 0.3 mg/kg over 30 to 60 seconds
General Anesthesia (Pediatric – IV Induction) mg 0.2 0.3 mg/kg
Sedation (IV – Initial) mg 0.1 0.2 mg/kg
Sedation (IV – Repeat Dose) mg 0.05 mg/kg every 3 to 5 min
Precedex
General Anesthesia (Continuous Infusion – Adjunctive Agent) mcg/hr 0.1 0.8 mcg/kg/hr titrate to desired effect
Sedation (IV – Initial Dose) mcg 0.5 1 mcg/kg over 10 min
Sedation (IV – Maintenance Dose) mcg/hr 0.2 1 mcg/kg/hr
Sedation (Pediatric – IV Initial Dose) mcg 0.5 2 mcg/kg
Sedation (Pediatric – IV Maintenace Dose) mcg/hr 0.5 1 mcg/kg/hr
Propofol
General Anesthesia (Induction – ASA 1 or 2) mg 1 2.5 mg/kg
General Anesthesia (Maintenance – ASA 1 or 2) mg/min 50 200 mcg/kg/min
General Anesthesia (Induction – ASA 3 or 4 or compromised) mg 0.5 1.5 mg/kg
General Anesthesia (Maintenance – ASA 3 or 4 or compromised) mg/min 50 100 mcg/kg/min
MAC (Initial Infusion) mg/min 25 75 mcg/kg/min
MAC (for Rapid Effect – Initial Infusion) mg/min 100 150 mcg/kg/min for 3 to 5 min
MAC (for Rapid Effect – Initial Bolus) mg 0.25 0.5 mg/kg
MAC (Intermittent Bolus) mg 10 20 mg
Sedation (Initial) mg 0.5 1 mg/kg
Sedation (Repeat Bolus) mg 0.25 0.5 mg/kg every 1 to 3 min
General Anesthesai (Pediatrics – Induction) mg 2.5 3.5 mg/kg over 20 to 30 seconds
General Anesthesia (Pediatrics – Maintenance Following Induction) mg/min 200 300 mcg/kg/min
General Anesthesia (Pediatrics – Maintenance >30 min following intubation) mg/min 125 150 mcg/kg/min
Sedation (Pediatrics – Initial Bolus) mg 1 2 mg/kg
Sedation (Pediatrics – Repeat Dose) mg 0.5 mg/kg every 3 to 5 min
Sedation (Pediatrics – Maintenace Infusion) mg/hr 1 8 mg/kg/hr
Rocuronium
RSI mg 0.6 1.2 mg/kg
Tracheal Intubation mg 0.45 0.6 mg/kg
Maintenance (bolus) mg 0.1 0.2 mg/kg
Maintenance (continuous infusion) mg/hour 0.01 0.012 mg/kg/min
Defasciculating Dose mg 0.03 0.06 mg/kg given 1.5 to 3 min before administration of succinylcholine
Vecuronium
Tracheal Intubation mg 0.08 0.1 mg/kg
Tracheal Intubation w/ succinylcholine mg 0.04 0.06 mg/kg
Maintenance (bolus) mg 0.01 0.015 mg/kg
Maintenance (continuous infusion) mg/hr 0.048 0.072 mg/kg/hr
Succinylcholine
Intubation mg 1 1.5 mg/kg
Ketamine
General Anesthesia (IM – Induction) mg 4 6 mg/kg
General Anesthesia (IV – Induction) mg 0.5 2 mg/kg
General Anesthesia (IV – Induction w/ TIVA) mg 0.25 0.35 mg/kg
General Anesthesia (IV – Maintenance w/ TIVA) mg/hr 1 mg/kg/hr
Sedation (Initial) mg 1 2 mg/kg over 1 to 2 min
Sedation (Repeat Dose) mg 0.5 1 mg/kg every 5 to 10 min
Sedation (IV – 1:1 mixture w/ propofol) mg 0.5 0.75 mg/kg 1:1 mixture w/ propofol
Sedation (IM – Initial Dose) mg 4 5 mg/kg
Sedation (IM – Repeat Dose) mg 2 5 mg/kg after 5 to 10 min
Sedation (Pediatric – IM Initial Dose) mg 4 5 mg/kg as a single dose
Sedation (Pediatric – IM Repeat Dose) mg 2 5 mg/kg after 5 to 10 min
Sedation (Pediatric – IM Minor Procedure) mg 2 2.5 mg/kg as a single dose
Sedation (Pediatric – IV Initial Dose) mg 1 2 mg/kg over 30 to 60 sec
Sedation (Pediatric – IV Repeat Dose) mg 0.5 1 mg/kg every 5 to 15 min
Midazolam
Sedation (IV – Initial Dose) mg 0.5 2 mg over ≥ 2 min
Sedation (IV – Repeat Dose) mg 0.5 2 mg repeat every 2 to 5 min 5 mg
Sedation (Pediatric – IM) mg 0.1 0.15 mg/kg 30 to 60 min before surgery 10 mg
Sedation (Children ≥ 6yrs) mg 0.025 0.05 mg/kg 10 mg
Sedation (Adloscents) mg 1 2.5 mg over ≥ 2 min 10 mg
Fentanyl
General Anesthesia (IV – Induction) mcg 25 100 mcg or 0.5 to 1 mcg/kg
General Anesthesia (IV – Intermittent Bolus) mcg 25 50 mcg as needed
Sedation (IV) mcg 0.5 1 mcg/kg every 2 min until desired effect 250 mg
Remifentanyl
General Anesthesia – (IV – Induction) mcg/min 0.5 1 mcg/kg/min
General Anesthesia – (IV – if Intubation <8min) mcg 1 mcg/kg over 30 to 60 sec
General Anesthesia – (IV – Maintenance) mcg 1 mcg/kg every 2 to 5 min
Sedation (IV – Single Dose) mcg 1 mcg/kg over 30 to 60 sec
Sedation (IV – Single Dose w/ Midazolam) mcg 0.5 mcg/kg over 30 to 60 sec
Sedation (IV – Continuous Infusion) mcg/min 0.1 mcg/kg/min beginning 5 min prior to local anesthesia
Sedation (IV – Continuous Infusion w/ Midazolam) mcg/min 0.05 mcg/kg/min beginning 5 min prior to local anesthesia
Sedation (IV – Continuous after LA) mcg/min 0.05 mcg/kg/min range 0.025 to 0.2 mcg/kg/min)
Sedation (IV – Continuous after LA w/ Midazolam) mcg/min 0.025 mcg/kg/min range 0.025 to 0.2 mcg/kg/min)
Diazepam
Presedation (IV- Initial Dose) mg 0.03 0.1 mg/kg 5 to 15 min prior to surgery 10 mg/dose
Presedation (IV- Repeat Dose) mg 0.015 0.05 mg/kg repeat dose after 5 to 30 min
Sedation (Oral – Children) mg 0.2 0.5 mg/kg 45 to 60min prior to surgery 10 mg
Sedation (Oral – Adolescents) mg 0.2 0.3 mg/kg 45 to 60min prior to surgery 10 mg
Sedation (IV – Infants/Children) mg 0.05 0.1 mg/kg over 3 to 5 min 0.5 mg/kg
Sedation (IV – Adolescents) mg 5 mg repeat with 2.5 mg if needed
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