Flumazenil and Narcan are used to reverse effects of benzodiazepines and narcotics, respectively. Atropine is an antimuscarinic and does not reverse deximedetomidine. Atipamezole is an alpha2-adrenoceptor antagonist with an imidazole structure. It rapidly reverses sedation/anesthesia induced by alpha2-adrenoceptor agonists. In humans, atipamezole at doses up to 30 mg produces no cardiovascular or subjective side effects, while at a high dose (100 mg) it produced subjective symptoms, such as motor restlessness, and an increase in blood pressure.
Dexmetatomidine (α2 agonist) – Atipamezole (α2 antagonist)
