Salivary Gland Pathology

Salivary gland tumors may involve major or minor glands, but the majority of cases are found within the parotid
gland. While most types of tumors may be found in both sites, relative frequency can vary. Thus, approximately
80% of parotid tumors are benign. In minor salivary glands, however, the benign-malignant ratio is closer to 1:1,
whereas in the sublingual gland, an uncommon site for neoplasms, the majority are malignant.

The pleomorphic adenoma is the most common tumor both in major and in minor salivary glands. Warthin tumors
(papillary cystadenoma lymphomatosum), basal cell adenomas, oncocytomas, acinic cell carcinomas, and sebaceous tumors have a strong predilection for the major glands, but the polymorphous low-grade adenocarcinoma has a marked predilection for the minor glands. While most intraoral salivary gland tumors favor the palate, the
canalicular adenoma favors the upper lip.

• Salivary Gland Aplasia
• Mucocele
• Ranula
• Salivary Duct Cyst
• Sialolithiasis
• Sialadenitis
• Cheilitis Glandularis
• Sialorrhea
• Xerostomia
• Benign Lymphoepithelial Lesion
• Sjögren Syndrome
• Sialadenosis
• Adenomatoid Hyperplasia of the Minor Salivary
• Glands
• Necrotizing Sialometaplasia

• Oncocytoma
• Oncocytosis
• Warthin Tumor
• Monomorphic Adenoma
• Canalicular Adenoma
• Basal Cell Adenoma
• Ductal Papillomas
• Mucoepidermoid Carcinoma
• Intraosseous Mucoepidermoid Carcinoma
• Acinic Cell Adenocarcinoma
• Malignant Mixed Tumors
• Adenoid Cystic Carcinoma
• Polymorphous Low-Grade Adenocarcinoma
• Salivary Adenocarcinoma, Not Otherwise Specified

BENIGN

• Pleomorphic adenoma (mixed tumor)
• Myoepithelioma
• Basal cell adenoma
• Canalicular adenoma
• Warthin tumor (papillary cystadenoma lymphomatosum)
• Oncocytoma
• Sebaceous adenoma
• Sebaceous lymphadenoma
• Ductal papillomas
• Sialadenoma papilliferum
• Intraductal papilloma
• Inverted ductal papilloma
• Papillary cystadenoma
• Sialoblastoma

MALIGNANT

• Malignant mixed tumors
• Carcinoma ex pleomorphic adenoma
•  Carcinosarcoma
• Metastasizing mixed tumor
• Mucoepidermoid carcinoma
• Acinic cell adenocarcinoma
• Adenoid cystic carcinoma
• Polymorphous low-grade adenocarcinoma
• Basal cell adenocarcinoma
• Epithelial-myoepithelial carcinoma
• Salivary duct carcinoma
• Myoepithelial carcinoma
• Cystadenocarcinoma
• Sebaceous adenocarcinoma
• Sebaceous lymphadenocarcinoma
• Clear cell adenocarcinoma
• Oncocytic carcinoma
• Squamous cell carcinoma
• Malignant lymphoepithelial lesion (lymphoepithelial carcinoma)
• Small cell carcinoma
• Adenocarcinoma, not otherwise specifi ed (NOS)