General Information Multi-dose vials of local anesthetics often contain preservatives such as parabens which are allergenic; this is not the case with single use dental cartridges. The presence of a vasoconstrictor usually is accompanied by an antioxidant such as a bisulfite which also may be allergenic, and should be avoided in cases of atopy Multi-use […]
Antibiotic Coverage Spectrum of Activity of Common OMFS Antibiotics Common OMFS Antibiotics Antimicrobial Therapy Penicillin Mechanism of Action D-Ala-D-Ala structural analog. Bind penicillin-binding proteins (transpeptidases) and blocks transpeptidase cross-linking or peptidoglycan cell wall. Activates autolytic enzymes. Mechanism of Resistance Penicillinase in bacteria (a type of β-lactamase) cleaves β-lactam ring. β-Lactamase Inhibitors Clavulonic acid, Avibactam, Sulbactam,
Precedex (Dexmetatomidine) Dexmedetomidine is a specific and selective alpha-2 adrenoceptor agonist. By binding to the presynaptic alpha-2 adrenoceptors, it inhibits the release if norepinephrine, therefore, terminate the propagation of pain signals. Activation of the postsynaptic alpha-2 adrenoceptors inhibits the sympathetic activity decreases blood pressure and heart rate. Benzodiazepines In order for GABAA receptors to be
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