Bone Pathology

Bone Pathology

Bone Pathology

Bone Pathology Fibro-Osseous Lesions Pathology

Osteogenesis Imperfecta Osteopetrosis Cleidocranial Dysplasia Focal Osteoporotic Marrow Defect Idiopathic Osteosclerosis Massive Osteolysis Paget’s Disease of Bone Central Giant Cell Granuloma Cherubism Simple Bone Cyst Aneurysmal Bone Cyst Fibrous Dysplasia Cemento-Osseous Dysplasias Familial Gigantiform Cementoma Ossifying Fibroma Juvenile Ossifying Fibroma Osteoma Gardner Syndrome Osteoblastoma and Osteoid Osteoma Cementoblastoma Chondroma Chondromyxoid Fibroma Synovial Chondromatosis Desmoplastic Fibroma Osteosarcoma […]

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Desmoplastic Fibroma

Desmoplastic Fibroma

Bone Pathology Pathology

Incidence age <30; no sex predilection Location mandible, femur, pelvic bones, radius, and tibia Clinical Features Tooth mobility, proptosis, concurrent infection, and dysesthesia are reported infrequently. If the lesion erodes through the cortex, then an accompanying soft tissue mass will be present. When this occurs, it may be difficult to determine whether the lesion is

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Ossifying Fibroma

Ossifying Fibroma

Bone Pathology Fibro-Osseous Lesions Pathology

AKA Cemetifying Fibroma, Cemento-Ossifying Fibroma Incidence rare; 3rd and 4th decade but can occur across a wide age range, female > male Clinical Presentation a true neoplasm (osteogenic neoplasm) with a significant growth potential. Composed of fibrous tissue that contains variable mixture of bony trabeculae and/or cementum-like spherules. Painless swelling causing obvious facial asymmetry. Rarely

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Cemento Osseous Dysplasia

Cemento-Osseous Dysplasia

Bone Pathology Fibro-Osseous Lesions Pathology

Focal vs Periapical vs Florid Most common fibro-osseous lesion Arise in close approximation with PDL ang have histopathologic similarities with the structure Histopathology: fragments of cellular mesenchymal tissue composed of spindle-shaped fibroblasts and collagen fibers with numerous small blood vessels Treatment: regular recall exam; unless symptomatic due to chronic osteomyelitis involving dysplastic bone and cementum,

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Fibrous Dysplasia

Fibrous Dysplasia

Bone Pathology Fibro-Osseous Lesions Pathology

Fibrous dysplasia is a developmental tumorlike condition that is characterized by replacement of normal bone by an excessive proliferation of cellular fibrous connective tissue intermixed with irregular bony trabeculae. Cause Sporadic condition that results from a postzygotic mutation in the GNAS1 (guanine nucleotide-binding protein, α-stimulating activity polypeptide 1) gene. Constitutive activation of G protein signaling

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Aneurysmal Bone Cyst

Aneurysmal Bone Cyst

Bone Pathology Pathology

Cause Intraosseous accumulation of variable-sized, blood filled spaces surrounded by cellular fibrous connective tissue and reactive bone. Theorized that traumatic event, vascular malformation, or neoplasm may disrupt normal osseous hemodynamics and leads to an enlarging, hemorrhagic extravasation. Incidence Gnathic lesions mainly affect young patients (mean age 20 years). No sex predilection Location Aneurysmal bone cysts

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Simple Bone Cyst

Simple Bone Cyst

Bone Pathology Pathology

AKA Traumatic bone cyst, hemorrhagic bone cyst, solitary bone cyst, idiopathic bone cyst Incidence Age 10 to 20 years old. Rare in children younger than 5 years and is seldom seen in patients older than 35. 60% in males Cause Trauma results in intraosseous hemorrhage which does not undergo organization and repair and liquefies, resulting

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Idiopathic Osteosclerosis 1

Idiopathic Osteosclerosis

Bone Pathology Pathology

AKA Dense bone island, bone eburnation, bone whorl, bone scar, enostosis, focal periapical osteopetrosis Cause Focal area of increased radiodensity that is of unknown cause and cannot be attributed to any inflammatory, dysplastic, neoplastic, or systemic disorders Incidence Increased frequency in blacks and Asians. No sex predilection. Most arise in late first or early second

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Focal Osteoporotic Marrow Defect 1

Focal Osteoporotic Marrow Defect

Bone Pathology Pathology

Cause Area of hematopoietic marrow that produces area of radiolucency. Can be a result of aberrant bone regeneration after tooth extraction, persistent fetal marrow, marrow hyperplasia in response to increased demand for erythrocytes. Incidence 75% are adult women Location 70% occur in posterior mandible, most often in edentulous areas Clinical Features Typically asymptomatic and found

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