Geriatric increases in anesthetic sensitivity is most closely associated with:a decrease in levels of neurotransmitters and receptors in different regions of the brain. In the elderly, there is a reduction in the number of neurons; this is matched by an decrease in the cerebral metabolic rate. The cerebral metabolic rate is directly related to the cerebral blood flow. The decrease in the neurons and neurotransmitters is related to a decrease in the cerebral blood flow